Xanthohumol for Human Malignancies: Chemistry,Pharmacokinetics and Molecular Targets

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.     

一次性使用医用手套标准解读

一次性医用手套是能够防止人们交叉感染的常用防护用品。随着新冠肺炎疫情在全球范围的迅速蔓延,疫情防控一线以及广大普通民众对一次性医用手套的需求与日俱增,其标准也受到广泛关注。本文对中国国家标准涉及一次性使用医用手套的4项产品标准进行了解读,并分析它们与国外同种产品标准间的对应关系以及重点指标的差异。     

浅析混凝土搅拌站的防雷

近年来,我市因雷击而导致搅拌站系统瘫痪停产、影响工程进度的事件时有发生,在针对混凝土搅拌站配料秤的实际检定工作中,也常发现配料秤的称重传感器因雷击损坏而影响计量准确性。因此,对混凝土搅拌站防雷的研究具有重要意义。本文阐述了雷电对混凝土搅拌站的主要危害,分析了混凝土搅拌站常见的雷击原因及其防护措施,旨在引起生产方、安装方以及使用方对混凝土搅拌站防雷的共同重视。     

黑龙江省节水增粮行动(2012—2015年)实施方案

文章通过对黑龙江省高效节水现状,存在问题的分析,结合黑龙江省高效节水发展的支撑能力,阐述黑龙江省节水增粮目标、任务及总体布局,为黑龙江省2012—2015年节水增粮实施提供依据。     

云冈矿采空区自然发火综合治理技术实践

针对云冈矿12#煤层8820、8822采空区出现CO泄漏事件,采用粉煤灰填充,构筑木板墙充填粉煤灰,配以墙体周边注马丽散堵漏;采用灌浆泵进行地面黄土灌浆,实施采空区灭火。通过对采空区自然发火进行综合治理,取得了良好效果,消除了自然发火隐患。     

陈四楼煤矿“123456双重预防体系”的建设与应用

针对煤矿“双重预防体系”如何落地生根问题，结合陈四楼煤矿在风险分级管控和隐患排查治理方面的实用方法和“双重预防体系”的建设经验，深入研究了“双重预防体系”的相关标准、风险隐患事故之间的关系及其各自的产生和发展机理、安全风险的有关辨识评估方法、事故隐患的排查和治理方法，分析了传统安全管理模式与“双重预防体系”的新型安全管理模式的差别，总结出了“123456双重预防体系”这个囊括了事前安全风险辨识、事中隐患排查治理、事后安全现状评估的创新成果，实现了“事前、事中、事后”的全过程控制，对夯实煤矿安全管理根基、促进矿井平稳有序发展发挥着越来越重要的作用，为煤炭行业“双重预防体系”的落地生根提供了借鉴和参考。     

浅谈农机报废更新工作开展的必要性

老旧农机具能耗高,尾气排放量大,对环境污染严重,在一定程度上影响了机具的规范使用和管理。文章对提升农机化发展水平,迫切需要开展农机报废更新工作指出其必要性,并提出了相关具体工作措施。     

Impact assessment of reservoir desiltation measures for downstream riverbed migration in climate change: A case study in northern Taiwan

Typhoon Aere in 2004 induced severe sedimentation and loss of storage capacity of the Shihmen Reservoir in northern Taiwan. The resulting dramatic increase in the turbidity of the water seriously affected the water supply. To effectively maintain the stability of the water supply and maintain the reservoir’s storage capacity, the government of Taiwan began to plan and construct a series of improvement measures, such as a sediment flushing tunnel, the JhongJhuang Bank-Side Reservoir, and the Amuping Desilting Tunnel. However, previous studies only focused on the impact of the sediment flushing tunnel and the Amuping Desilting Tunnel on the downstream riverbed, and did not consider the possibility of increasing sediment discharge after the completion of the JhongJhuang Bank-Side Reservoir. In addition, climate change will cause the intensity of extreme rainfall to increase enormously in the future. That rainfall and extra sediment flushing will challenge the existing flood prevention facilities. Therefore, this study considered that the JhongJhuang Bank-Side Reservoir will increase sediment discharge of the Shihmen Reservoir, and used dynamical downscaling extreme typhoon data of climate change under the RCP 8.5 scenario to explore the flood prevention and riverbed migration of the main channels of the Dahan and Tamsui Rivers in the future. We used the rainfall–runoff model of Hydrologic Modeling System to simulate rainfall and runoff, and used the hydraulic and sediment transport model of CCHE1D to holistically simulate flood events and consequent river scouring and deposition behaviors. Our results showed that the projected peak discharge during the late 21st century (2075 to 2099) will be at least 50% higher than that during the baseline (1979 to 2003) period. In terms of flood prevention, the potential of overbank flooding will increase in the downstream area, and the trend of long-term change in the riverbed will be dominated by degradation (-0.489 ± 0.743 m) in the future. The improvement measures will have a limited impact on riverbed migration (0.011 ± 0.094 m) in the Dahan and Tamsui Rivers. After the operation of the JhongJhuang Bank-Side Reservoir, the Shihmen Reservoir is expected to increase the sediment discharge ratio by 70% during floods, and it will not cause excessive water turbidity that may affect downstream water supply.     

煤巷过断层破碎带施工工艺与支护技术实践

W1313回风顺槽在里程332 m处揭露正断层,对此采取了调整巷道顶板锚网索支护参数,采用圆木大板棚复合支护等措施,并加强了顶板、通风、掘锚机破岩、爆破作业和作业人员的安全管理,确保工作面过断层破碎带时的安全施工。